Toxicokinetics


 
Dosimetric and toxicokinetic information is required to determine metabolic pathways, the distribution of parent compounds and metabolites to target sites, the doses of drugs or toxicants required for therapeutic or toxic effects, and interspecies differences important in estimating human risk.
 

 

LRRI has broad capabilities in this field, and is especially recognized as a major center for the dosimetry of inhaled compounds. Leading-edge analytical chemistry and radioanalytical capabilities are combined with expertise in inhalation exposure, biochemistry, toxicology, and pathology to resolve the fate of toxicants in the body, doses to target tissues, and markers in fluids, tissues, and excreta.

These capabilities are integrated to provide information required to understand health risks, optimize the efficacy of pharmaceuticals, and select laboratory species most predictive of human responses.

Key Capabilities:

  • Exposures by inhalation to gases, vapors, and aerosols, and to dermally applied, ingested, instilled, or injected compounds
  • Work with hazardous chemicals, radiolabeled compounds, and radioactive agents, including approved waste streams
  • Full range of laboratory animal species and in vitro systems for testing
  • Analytical instrumentation including high-pressure liquid chromatography (HPLC), fast protein liquid chromatography (FPLC), electrospray ionization mass spectrometry (LC-MS/MS), gas chromatography and gas chromatography/mass spectrometry (GC/MS), capillary electrophoresis, UV-VIS spectroscopy, matrix-assisted laser desorption/ionization mass spectrometry (MALDI); and Surface-Enhanced Laser Desorption/Ionization (SELDI) mass spectrometry
  • Compliance with Good Laboratory Practice regulations and other customer requirements
  • Confidentiality, proprietary, and intellectual property agreements
  • Collaboration with customer's in-house investigations

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