Aerosol Technology


 

 
LRRI offers internationally recognized expertise in aerosol science and inhalation exposure technology.  These technologies can be used for research and development on aerosol generation and delivery techniques, sampling instrumentation and strategies, dosimetry of inhaled particles, characterization of radioactive particles, evaluation of decontamination technology, and personal protection strategies.
 

 

Our aerosol scientists are experienced in computer simulation, laboratory experiments, and field studies as well as in handling a broad range of airborne materials, including powders, fibers, toxic chemicals, nanomaterials, radionuclides, viruses, bacteria, and fungi.  We also have BSL-3 labs to perform tests using live agents.  Our facilities are unique because we can handle hazardous materials that many laboratories cannot. 

LRRI provides a distinct ability to apply all of these technologies in an ABSL-3 and/or a BSL-3 setting for use with live agents.  This allows our facility to work with nearly any aerosol material regardless of hazards. 

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Key Capabilities:

Drug Delivery and Inhalation Therapy

  • Characterizing the performance of nebulizers, metered dose inhalers, dry powder inhalers, and nasal sprays
  • Deposition patterns in realistic airway casts of the human nasal, oral, and tracheobronchial regions
  • Deposition pattern using gamma scintigraphy

Generation and Characterization

  • Design and test vapor and aerosol dissemination equipment for special test facilities
  • Design and test dissemination methods for simulants, live agents, chemical agents, and radioactive materials
  • Develop sampling strategy and instrumentation for monitoring live agents, chemical agents, and radioactive materials

Design and Test of Air Sampling Instruments

  • Calibration of aerosol sampling instruments including personal samplers and aerosol collectors in wind tunnel facilities
  • Calibrate bioaerosol detectors with simulants and live agents
  • Evaluate chemical detectors with simulants and chemical agents

Characterization of Radioactive Material

  • Dissolution rates of radioactive materials
  • Biokinetics of inhaled radioactive materials in lab animals
  • Evaluation of continuous air monitors using radioactive aerosols

Decontamination and Personal Protection Equipment

  • Evaluate decontamination technology using chemical/biological simulants and live agents
  • Evaluate respirator performance using simulants and live agents
  • Evaluate air cleaners, filters, and control technologies for particulate matter

Stack Monitoring in Nuclear Facilities

  • Perform field studies to qualify stack sampling locations  Design scaled stack models and perform qualification tests following the ANSI N13.1-1999 requirements

Inhalation Studies - Exposure Facilities/Equipment

  • Over 30,000 square feet of specialized laboratories for conducting exposures
  • Over 100 whole-body exposure chambers
  • 26 nose-only exposure chambers (24- to 96-port)
  • Capabilities of operating exposure systems with up to 13 whole-body chambers/room, or 6 nose-only chambers/room
  • Expertise in conducting nasal, oral, or whole-body inhalation exposures of laboratory animals (including rodents, dogs, non-human primates) and human subjects
  • Capabilities for conducting GLP-compliant inhalation toxicity studies
  • Acute, subchronic (90 day), chronic (18 mo up to 30 mo)
  • Capabilities for generating gases, vapors, powders, fibers, mists, combustion products, hazardous, toxic, and radioactive exposure atmospheres

Specialized Facilities

  • Aerosol wind tunnels for evaluation of sampling instrumentation
  • Bioaerosol chambers for evaluating biodetectors and dissemination techniques
  • Special laboratory for testing chemical agents
  • BSL-3 facilities for live agents
  • Radiation laboratories for working with radioactive aerosols
  • Gamma scintigraphy laboratory