Biosafety Level Three (BSL-3, ABSL-3) Facilities

 

 
Extensive BSL-3 and ABSL-3 level facilities are available for collaborative or contract work with LRRI. The ABSL-3 facilities allow for inhalation exposure of pathogens for efficacy studies. The facilities have been cleared by the CDC for the handling of Select Agents and toxins.
 

 

LRRI's Select Agents registration allows LRRI to conduct research using the agents listed below in vitro and in vivo (in these animals: mice, rats, guinea pigs, hamsters, rabbits, ferrets, dogs, nonhuman primates) for instillation (aerosol, intranasal, intratracheal, intraperitoneal, intravenous, oral, gastric [gavage], subcutaneous, dermal, intracerebral).

LRRI Select Agents Registration:

Abrin

Avian influenza virus (highly pathogenic)

Bacillus anthracis

Botulinum neurotoxins

Brucella abortus

Brucella melitensis

Brucella suis

Burkholderia mallei (formerly Pseudomonas mallei)

Burkholderia pseudomallei (formerly Pseudomonas pseudomallei)

Clostridium perfringens epsilon toxin

Coccidioides posadasii

Coccidioides immitis

Conotoxins

Coxiella burnetii

Diacetoxyscirpenol

Eastern equine encephalitis virus

Flexal South American haemorrhagic fever virus

Francisella tularensis

Monkeypox virus

Ricin

Rickettsia prowazekii

Rickettsia rickettsii

Saxitoxin

Shigatoxin

Staphylococcal enterotoxins

T-2 toxin

Tetrodotoxin

Venezuelan equine encephalitis virus

Yersinia pestis

Key Capabilities:

  • Animal BSL-3 facility with aerosol exposure capabilities
  • 35 trained aerosol, toxicology, and exposure personnel at the PhD/MS/BS level
  • Numerous rodent, ferret, nonhuman primate, and rabbit models are available
  • Registered with CDC under laboratory registration for Select Agent Transfer program
  • AAALAC, FDA, USDA, state, and other regulatory licensure in hand