Animal Models of COPD


The study of animal models of COPD and COPD exacerbation is useful for both understanding the mechanisms of this disease and for developing useful therapies.  These animal models will continue to be used widely by pharmaceutical industry and individual investigators in the field to identify early markers for COPD and to test new drugs based on the identification of novel mechanisms of disease.


1. LRRI has expertise in measuring wood smoke concentrations in homes to study the role of wood smoke in exacerbating COPD. 

2. LRRI has exposed mice to defined concentrations of wood smoke, motor vehicle exhaust, ozone, and other pollutants to determine their roles in exacerbating cigarette smoke-induced COPD.

3. LRRI has generated aerosols of various drugs and exposed the animal models to defined particle size and concentrations to determine the role of the drugs in affecting inflammation, chronic bronchitis or emphysema. 

4. LRRI has a long history of testing the efficacy of numerous drugs using in vitro and in vivo animal models of COPD.  Findings from these studies can then be tested in clinical trials. 

5. Effect of nutrition on the development of emphysema.
2015 Publications
Why Do We Need a Nonhuman Primate Model of Smoking-Induced COPD?
By Jeffrey L. Curtis and Christine M. Freeman (Adobe PDF Document)

This Commentary highlights the article by Polverino et al, describing the development of a novel nonhuman primate model of cigarette smoke-induced chronic obstructive pulmonary disease.
Copyright © 2014 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved. PMID: 25576784